Cytokine systems approach demonstrates differences in innate and pro-inflammatory host responses between genetically distinct MERS-CoV isolates.
Identifieur interne : 001668 ( Main/Exploration ); précédent : 001667; suivant : 001669Cytokine systems approach demonstrates differences in innate and pro-inflammatory host responses between genetically distinct MERS-CoV isolates.
Auteurs : Christian Selinger [États-Unis] ; Jennifer Tisoncik-Go [États-Unis] ; Vineet D. Menachery [États-Unis] ; Sudhakar Agnihothram [États-Unis] ; G Lynn Law [États-Unis] ; Jean Chang [États-Unis] ; Sara M. Kelly [États-Unis] ; Pavel Sova [États-Unis] ; Ralph S. Baric [États-Unis] ; Michael G. Katze [États-Unis]Source :
- BMC genomics [ 1471-2164 ] ; 2014.
Descripteurs français
- KwdFr :
- Analyse de profil d'expression de gènes, Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie), Cytokines (pharmacologie), Facteur de transcription STAT-3 (métabolisme), Facteurs temps, Génomique, Humains, Immunité innée (), Inflammation (virologie), Interactions hôte-pathogène (immunologie), Lignée cellulaire.
- MESH :
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient.
- immunologie : Interactions hôte-pathogène.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient.
- métabolisme : Facteur de transcription STAT-3.
- pharmacologie : Cytokines.
- physiologie : Coronavirus du syndrome respiratoire du Moyen-Orient.
- virologie : Inflammation.
- Analyse de profil d'expression de gènes, Facteurs temps, Génomique, Humains, Immunité innée, Lignée cellulaire.
English descriptors
- KwdEn :
- Cell Line, Cytokines (pharmacology), Gene Expression Profiling, Genomics, Host-Pathogen Interactions (immunology), Humans, Immunity, Innate (drug effects), Inflammation (virology), Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (isolation & purification), Middle East Respiratory Syndrome Coronavirus (physiology), STAT3 Transcription Factor (metabolism), Time Factors.
- MESH :
- chemical , metabolism : STAT3 Transcription Factor.
- chemical , pharmacology : Cytokines.
- drug effects : Immunity, Innate.
- genetics : Middle East Respiratory Syndrome Coronavirus.
- immunology : Host-Pathogen Interactions.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- physiology : Middle East Respiratory Syndrome Coronavirus.
- virology : Inflammation.
- Cell Line, Gene Expression Profiling, Genomics, Humans, Time Factors.
Abstract
The recent emergence of a novel coronavirus in the Middle East (designated MERS-CoV) is a reminder of the zoonotic and pathogenic potential of emerging coronaviruses in humans. Clinical features of Middle East respiratory syndrome (MERS) include atypical pneumonia and progressive respiratory failure that is highly reminiscent of severe acute respiratory syndrome (SARS) caused by SARS-CoV. The host response is a key component of highly pathogenic respiratory virus infection. Here, we computationally analyzed gene expression changes in a human airway epithelial cell line infected with two genetically distinct MERS-CoV strains obtained from human patients, MERS-CoV SA 1 and MERS-CoV Eng 1.
DOI: 10.1186/1471-2164-15-1161
PubMed: 25534508
Affiliations:
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Clinical features of Middle East respiratory syndrome (MERS) include atypical pneumonia and progressive respiratory failure that is highly reminiscent of severe acute respiratory syndrome (SARS) caused by SARS-CoV. The host response is a key component of highly pathogenic respiratory virus infection. Here, we computationally analyzed gene expression changes in a human airway epithelial cell line infected with two genetically distinct MERS-CoV strains obtained from human patients, MERS-CoV SA 1 and MERS-CoV Eng 1.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Caroline du Nord</li><li>Washington (État)</li></region><settlement><li>Seattle</li></settlement><orgName><li>Université de Washington</li></orgName></list><tree><country name="États-Unis"><region name="Washington (État)"><name sortKey="Selinger, Christian" sort="Selinger, Christian" uniqKey="Selinger C" first="Christian" last="Selinger">Christian Selinger</name></region><name sortKey="Agnihothram, Sudhakar" sort="Agnihothram, Sudhakar" uniqKey="Agnihothram S" first="Sudhakar" last="Agnihothram">Sudhakar Agnihothram</name><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S" last="Baric">Ralph S. Baric</name><name sortKey="Chang, Jean" sort="Chang, Jean" uniqKey="Chang J" first="Jean" last="Chang">Jean Chang</name><name sortKey="Katze, Michael G" sort="Katze, Michael G" uniqKey="Katze M" first="Michael G" last="Katze">Michael G. Katze</name><name sortKey="Kelly, Sara M" sort="Kelly, Sara M" uniqKey="Kelly S" first="Sara M" last="Kelly">Sara M. Kelly</name><name sortKey="Law, G Lynn" sort="Law, G Lynn" uniqKey="Law G" first="G Lynn" last="Law">G Lynn Law</name><name sortKey="Menachery, Vineet D" sort="Menachery, Vineet D" uniqKey="Menachery V" first="Vineet D" last="Menachery">Vineet D. Menachery</name><name sortKey="Sova, Pavel" sort="Sova, Pavel" uniqKey="Sova P" first="Pavel" last="Sova">Pavel Sova</name><name sortKey="Tisoncik Go, Jennifer" sort="Tisoncik Go, Jennifer" uniqKey="Tisoncik Go J" first="Jennifer" last="Tisoncik-Go">Jennifer Tisoncik-Go</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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